Recent Global Initiatives in the Department of Pathology & Laboratory Medicine

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PIPartner OrganizationYearCountryType Activities
Dorovini-Zis, Katerina TFRI, Dept of Pathology UBC, University Medicine and Pharmacy (UMP) in Ho Chi Minh City, Vietnam2017VietnamEducation and TrainingAlong with Dr. Stephen Yip, we recently visited the University Medicine and Pharmacy (UMP) in Ho Chi Minh City, Vietnam, for a 3-day intense teaching on brain tumors in the Department of Pathology and consultation on neurosurgical cases with the Department of Pathology Faculty. read more..
Dorovini-Zis, Katerina VGH, Blantyre, Michigan State University, UBC and U. Pennsylvania2013-presentMalawi, AfricaResearch CollaborationFor the last 15 years I have been involved in an international study of cerebral malaria originating from Malawi, Africa with collaborating physician-scientists from Blantyre, Michigan State University, UBC and U. Pennsylvania. Keep Reading
Yip, Stephen TFRI, Dept of Pathology UBC, University Medicine and Pharmacy (UMP) in Ho Chi Minh City, Vietnam2017VietnamEducation and TrainingBeen invited by the University of Medicine & Pharmacy in Ho Chi Minh City to provide a course on update of brain tumor diagnosis (w emphasis of the new WHO classification). This effort is supported by the TFRI and Dept of Pathology at UBC. Members from multiple pathology departments in the city will attend. The current plan is to do a three day course in the first week of October 2017. I will also bring over glass slides as well as Aperio scanned files. I also plan to help the UMP lab set up IDH1 R132H IHC testing by bringing over blank slides of cases confirmed to exhibit this mutation and also to bring over CIQC low grade glioma slides. read more..


UPDATE: MAY 2018 I have received a consult from VN - via lots of BMP files. I think if we can do this via e-pathology that would be much better. Even better is if we can do this and converse with the originating pathologist online while reviewing the slide.
Yip, StephenVGH2018IndonesiaEducation and TrainingThis year I might be going to Jakarta (Indonesia) to do some teaching in brain tumour pathology as part of a team organized by the neurosurgery group. There are ongoing visits by one of the neurosurgeon to Indonesia to improve neurosurgical management of patients and there is a plan to develop a one day seminar in April or May this year with me and another neurosurgeon to disseminate additional information. I will be communicating with some of the surgical pathologists there that are managing the brain tumour sign outs.
Yip, StephenChinese University HK (Prince of Wales Hospital) 2012-presentChinaResearch CollaborationI am collaborating with Dr HK Ng, neuropathologist at Chinese University HK (Prince of Wales Hospital) on several projects but notably on a sequencing project of rare brain tumours. He has sent over frozen tissue and matched blood of several cases of which we have performed whole genome sequencing, 850K methylation analysis and all proceed with RNA-SEQ of selected cases with publication being the ultimate goal. Also, HK as well as his neurosurgical colleagues Dr Danny Chan, had invited me several times to Hong Kong as a speaker for the annual BRAIN meeting at Chinese University HK. Lastly, I was the visiting professor in at Prince of Wales Hospital in 2012 during which I conducted a two day course on molecular pathology of brain tumours.
Mackenzie, Ian Project MinE, Netherlands2017-presentNetherlandsResearch CollaborationInvolved in Project MinE - and International ALS Genetics Project Keep Reading
Mackenzie, Ian National Institutes of Health, The National Institute on Aging , Bethesda, Maryland USA2014-2019USAResearch CollaborationAdvancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL). US based North American studies on FTD

Noble, Michael Clinical Microbiology Proficiency Testing (CMPT)2015-presentSouth AfricaEducation and TrainingEQA materials and services
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CMPT accreditation (ISO17043:2010 and ISO9001:2015) is internationally recognized and accepted. CMPT is seen as a valued provider of quality samples, innovation, and outreach education. CMPT is unique in that it provides Quality Assurance program both for medical laboratories and for public health drinking water (and recreational water) laboratories. All the international participants are current and sustainable and scalable, with the only limiting factor being international transport requirements. Partnering with international partners can increase outreach.
Noble, Michael Clinical Microbiology Proficiency Testing (CMPT)2015-presentVietnamEducation and TrainingEQA materials and services
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CMPT accreditation (ISO17043:2010 and ISO9001:2015) is internationally recognized and accepted. CMPT is seen as a valued provider of quality samples, innovation, and outreach education. CMPT is unique in that it provides Quality Assurance program both for medical laboratories and for public health drinking water (and recreational water) laboratories. All the international participants are current and sustainable and scalable, with the only limiting factor being international transport requirements. Partnering with international partners can increase outreach.
Noble, Michael Clinical Microbiology Proficiency Testing (CMPT)2015-presentBermudaEducation and TrainingEQA materials and services
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CMPT accreditation (ISO17043:2010 and ISO9001:2015) is internationally recognized and accepted. CMPT is seen as a valued provider of quality samples, innovation, and outreach education. CMPT is unique in that it provides Quality Assurance program both for medical laboratories and for public health drinking water (and recreational water) laboratories. All the international participants are current and sustainable and scalable, with the only limiting factor being international transport requirements. Partnering with international partners can increase outreach.
Noble, Michael Clinical Microbiology Proficiency Testing (CMPT)2015-presentGreeceEducation and TrainingEQA materials and services
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CMPT accreditation (ISO17043:2010 and ISO9001:2015) is internationally recognized and accepted. CMPT is seen as a valued provider of quality samples, innovation, and outreach education. CMPT is unique in that it provides Quality Assurance program both for medical laboratories and for public health drinking water (and recreational water) laboratories. All the international participants are current and sustainable and scalable, with the only limiting factor being international transport requirements. Partnering with international partners can increase outreach.
Noble, MichaelClinical Microbiology Proficiency Testing (CMPT), University of Montreal2015-presentBotswana (Currently being offered as a CPD course for laboratory technologists in Botswana via a collaboration within the University of Montreal )Education and TrainingContinuing Professional Development Course. CMPT CPD is an on-line education course through which participants can earn CPD credits from CSMLS. Mainly designed for Canadian laboratory technologists. Keep Reading

Currently in its third year of delivery. We have not sought out other delivery partners. We have not promoted this as a sustainable program for international participants, but will continue to provide provided that countries participants are competent in English and see educational value in the materials. Has potential to be scalable with some efforts towards awareness and promotion. Ample opportunities for international promotion.
Noble, MichaelClinical Microbiology Proficiency Testing (CMPT)2011-2016In the past countries that have come for PT/EQA training include:Thailand, South Africa, Zimbabwe, China, Turkey, Oman, UAE, BelgiumEducation and TrainingOver the past 20 years CMPT has invited technologists from developing (and other) countries to come to CMPT and learn our techniques for creation and delivery of clinical and water samples.

The program is sustainable and scalable but not with the current model of delivery because it is too expensive to have people come to Vancouver. CMPT is currently in discussion with an international deliverer of PT/EQA programs and with the Africa Center for Disease Control to extend training. For CMPT to be actively involved with require working through UBC UILO.
Noble, MichaelProgram Office for Laboratory Quality Management (POLQM)2004-presentFrom the beginning there has been sustained participation from United States, Saudi Arabia (and other middle eastern countries) and southern countries including Mexico and Caribbean nationsEducation and TrainingPOLQM developed its UBC CPD accredited on-line course in Laboratory Quality Management. Primarily intended for the Canadian laboratory technologists.

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POLQM regular course (January-June) has been running for 15 years and is current and sustainable. Because of the intense “real-time” VCOLE (Virtual Classroom On-line Education) style of delivery it is probably at its near maximum participation.
Noble, MichaelProgram Office for Laboratory Quality Management (POLQM); University of Washington2015-presentUSA. U. Washington –International Training and Education Center for HealthEducation and TrainingPOLQM developed its UBC CPD accredited on-line course in Laboratory Quality Management. Designed for an international audience through collaborations with University of Washington

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The POLQM (International) is in its second year of delivery and is funded through June 2019. The program is well received and is founded on a solid foundation of cooperation and collaboration and has great potential for sustainability and scalability, provided that UBC internal barriers (UBC Office of Legal Council) can be overcome.
Noble, MichaelProgram Office for Laboratory Quality Management (POLQM); University of Washington2015-presentZambia – Training Program for 16 Quality ManagersEducation and TrainingPOLQM developed its UBC CPD accredited on-line course in Laboratory Quality Management. Designed for an international audience through collaborations with University of Washington


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The POLQM (International) is in its second year of delivery and is funded through June 2019. The program is well received and is founded on a solid foundation of cooperation and collaboration and has great potential for sustainability and scalability, provided that UBC internal barriers (UBC Office of Legal Council) can be overcome.
Noble, MichaelProgram Office for Laboratory Quality Management (POLQM); University of Washington2015-presentCambodia Education and TrainingPOLQM developed its UBC CPD accredited on-line course in Laboratory Quality Management. Designed for an international audience through collaborations with University of Washington


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The POLQM (International) is in its second year of delivery and is funded through June 2019. The program is well received and is founded on a solid foundation of cooperation and collaboration and has great potential for sustainability and scalability, provided that UBC internal barriers (UBC Office of Legal Council) can be overcome.
Noble, MichaelCMPT, European Organization for Quality Assurance in Laboratory Medicine (EQALM)2015-presentTrans-Europe/North America/AustraliaResearch CollaborationInternational Survey Study on Laboratory Reporting for Antibiotic Resistance. International Survey Study on Laboratory Reporting of Enteric Pathogens.

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EQALM is the international organization for PT/EQA. CMPT is a long term member and active participant. Dr. Noble is the Chair of the EQALM Microbiology Working Group. EQALM has a mandate to seek and develop collaborative international studies around PT/EQA. CMPT participation is both current and sustainable.
Noble, MichaelCMPT, International Organization for Standardization (ISO)1994-presentInternational Education and TrainingDevelopment of International Standards for Medical Laboratory Quality including ISO15189:2003/2007/2012 ISO9001:2015

ISO is the crafting body for accreditation standards for PT/EQA and other laboratory fields. CMPT relationship is current and potentially sustainable.
Noble, MichaelClinical and Laboratory Standards Institute in Tanzania2005-2010TanzaniaEducation and Training Senior Technical Advisor for Clinical and Laboratory Standards Institute – Laboratory Strengthening Program – Africa

Designed and Developed the step-wise improvement and accreditation program for medical laboratories in Tanzania
Noble, MichaelCenters for Disease Control and Prevention (Atlanta)2000-2005USAEducation and TrainingIntermittent Expert – Laboratory Quality Management

Developed and Co-Chair of Global Odyssey (2002) – International Conference for Microbiology Proficiency Testing
Noble, MichaelWorld Health Organization 2016-2017Switzerland, Geneva Education and TrainingChair, Committee of Document Development (EQA for Developing Countries)

Developed the WHO Guidance Document for EQA for Developing Countries.
Noble, MichaelWorld Health Organization2007-2008Switzerland, Geneva Education Advisor

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CDC-WHO-CLSI Quality Management Education Project for Developing Countries
Noble, MichaelDiagnostic Microbiology Development Program (DMDP)2018-presentCambodiaEducation and TrainingConsultant. Advisor for the development of microbiology EQA for Cambodia
Noble, MichaelCMPT Training Program2018-presentAfricaEducation and TrainingLead Microbiology EQA sample production program. Train developing country programs to create their own microbiology EQA samples (note: this is an extension of the aforementioned CMPT Training Program. Rather than providing training in Canada, we will go to the country and provide training in their facilities)
Huynh, Hahn UBC, (Global Health Clinical Elective for UBC 4th year Medical Students), University of Medicine and Pharmacy (UMP) in Saigon, Vietnam2013-presentVietnamEducation and TrainingSince 2013, an average of 15 to 20 students (4th year UBC Medicine) applies to do a 4 to 6 week clinical elective with the University of Medicine and Pharmacy (UMP) in Saigon tertiary hospital. These include Infectious Diseases, Surgery, Radiology, Pediatrics, Internal Medicine. Please see attached sampled exit survey and written experiences about the elective that a UBC Med Student just completed in Surgery. For the spring of 2018, a total of 20 UBC Med students will participate in this elective. The plan is to continue with this elective as long as UMP can accommodate UBC Med Students. Keep Reading
Huynh, Hahn Collaboration with UMP and The Nutrition Center in Saigon, Vietnam2012-presentVietnamEducation and TrainingEvery year (since 2012), I chair and give talk at the Nutrition Conference in Saigon as part of the collaboration in updating medical doctors in Vietnam about Prevention of Non Communicable Diseases (Overweight, Obesity, Diabetes and Cancer) from the lens of Immunology. I have also been invited to give CME talk for UMP Faculty on these occasions. For 2017, I gave a talk on Pediatric Obesity: Updates on Mechanism and Treatment to UMP Pediatric Faculty in mid Aug 2017 in Saigon. I plan to continue to collaborate with the Nutrition Center and UMP as long as the opportunity is there.

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Huynh, Hahn Collaboration between UBC Pathology, Pediatrics, UMP and Terry Fox Run Committee Vietnam (TFRCV)2017-presentVietnamEducation and TrainingThe goal is to establish/develop Pediatric Oncology for Vietnam. TFRCV provides the fund (raised from the TF run in VN annually) to support the development of Fellowship in Pediatric Oncology at BC Children Hospital. The first UMP Pediatric Faculty will be participating in this 2 year Fellowship in the near future (as soon as all requirements are met). Expected to start in early 2019. TFRCV has also approved funding for a 2 year fellowship training program for a UMP Pathologist; the required logistics are being developed to accommodate this Fellow, and it is expected to start in July 2019. In addition to the development of the above fellowship programs, TFRCV also support the cost of flight and accommodation for UBC Pathologists to go to UMP for teaching/sharing expertise with UMP Pathology Faculty. Both Katerina Dorovini-Zis and Stephen Yip had been teaching at UMP Pathology in the first week of Oct 2017, this is the first step in supporting the development of Neuropathology for UMP Pathology. UBC Pathology shared the flight cost with TFRCV on this one. TFRCV paid for the hotel and UMP pays for the food of UBC Pathologists during their stay. Due to the success of Drs Zis’ & Yip’s teachings, TFRCV has agreed to fund UBC Pathologists’ travel expenses (ie. Flight and accommodation in Saigon Vietnam) when they volunteer to teach at UMP. The above programs (ie. Fellowship & Teaching at UMP Pathology) will be maintained as long as there is sufficient fund in the TRFCV and volunteering UBC Pathologists.

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Cimolai, Nevio Medical journals1999-PresentInternational Education and TrainingCurrently function as an Editor and member of the Editorial Board for the Canadian Journal of Microbiology. The majority of manuscripts being submitted to the journal are from international sources, probably including 1/3 to 1/2 of the countries of the world. Also have reviewed for multiple international medical journals on a yearly basis, sometimes up to 10 or more international journals. Have also provided for book reviews re: international publishers. Contributed one book chapter this year for a book written by an international group, principally authored by an American.
Garg, Arun Canada India Network Society2010-presentIndiaEducation and TrainingSince 2010, actively pursuing links with India. Funded a not for profit Canada India Network society. It was established in recognition that there is a need to have informal links and network within Canadian and Indian professionals. Organized global conference in 2010 and 2014. Now planning one for 2018.Both were covered in pathology Bulletin. Working on exchange with Dr Lal’s laboratories and collaborated with Annamalai University in a project on role of salt in Indian Diet. Paper published in Int J of Hypertension. Also supported development of Human Resources Strategy in Med Lab technologist training. Worked with Public health foundation of this project. CINI 201 theme was cardiovascular diseases, 2014 was health and Civil society. 2018 is health Civil Society through innovation, technology and engagement. Actively pursuing global programs both locally and India. In India working with Govt of India, M/Health on support for Human Resources-Allied health ( with BCIT- Med lab Program), Technology application for rapid diagnosis of TB in remote villages using Lamp technology ( with BCIT- Research Centre), completed a study on role of salt in Indian diet( in collaboration with Annamali University), exploring exchange program for pathologists with country’s largest community lab Dr Lals Lab in New delhi. Supporting development of leadership and Professionalism for Physicians .In conjunction with Dr Graham Dickson of Royal Road University and GAPIO). . Executive member of Global Association of Physicians of Indian Origin. Locally working with Fraser health to develop South Asian health services, which are scalable and applicable to population at large. Key project on behavior modification and life style changes to reduce non communicable chronic diseases.

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Krajden, Mel Australia, Scotland and BC2015-presentAustralia, Scotland and BCResearch CollaborationWe have been involved with comparing and analysing data on hepatitis C disease burden between Australia, Scotland and BC. Aspinall EJ1, Hutchinson SJ2, Janjua NZ3, Grebely J4, Yu A3, Alavi M4, Amin J4, Goldberg DJ2, Innes H2, Law M4, Walter SR5, Krajden M3, Dore GJ4. Trends in mortality after diagnosis of hepatitis C virus infection: an international comparison and implications for monitoring the population impact of treatment. J Hepatol. 2015 Feb;62(2):269-77. doi: 10.1016/j.jhep.2014.09.001. Epub 2014 Sep 6. Collaborating on understanding global HCV prevalence Polaris Observatory HCV Collaborators. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study. Lancet Gastroenterol Hepatol. 2017 Mar;2(3):161-176. doi: 10.1016/S2468-1253(16)30181-9. Epub 2016 Dec 16

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Alaghehbandan, Reza World Health Organization2018International Education and TrainingConsultant, Expert Panel on Cancel Control (Anatomic Pathology), World Health Organization (WHO), Apr. 2018-present (serving as an expert on cancer control at the World Health Organization (WHO) concerning operational guide to building pathology capacity in low-resource countries .)
Alaghehbandan, Reza National Health Laboratory in Gaborone2015-presentBotswanaEducation and TrainingMy honor and privilege to help colleagues and patients in Sub-Saharan Africa (Botswana) with teaching, clinical sign-out, and consultations. I still provide long distance educational assistance to Botswana pathology residents. As a UBC clinical faculty, the Sub-Saharan Africa experience (Nov. 2015) was featured and highlighted by the US and Canadian Academy of Pathology (USCAP), which is the most prestigious International body in the field of Anatomic Pathology. Please see page 10 article entitled “Philanthropy: The Essence of Pathology Global Health”: Keep Reading
Alaghehbandan, Reza Khon Kaen University (KKU), Northern Thailand2017-presentThailandEducation and TrainingBeen invited as a visiting professor to the Khon Kaen University (KKU) in Northern Thailand. Activities included doing workshops and consultations for local pathologists and teaching pathology trainees. Also met with the Dean of Medicine who expressed his wish for a more formal networking and collaboration between the UBC and KKU. Their University acts as an educational hub for assisting neighboring countries such as Laos, Cambodia etc. I have been invited by the Thai Royal College of Pathologists’ President to visit them next year in Bangkok for lecture and teachings at their IAP branch meeting. Similar invitations have been given from the KKU to help improving their surgical pathology practices in collaborations with surgeons (I will be visiting them early next year as well).
Alaghehbandan, Reza 2017-PresentLaos Education and TrainingAlso had the honor to recently visit Laos and work with colleagues and patients in Vientiane (Nov. 2017). This included meetings with the University officials, physicians, surgeons, and the patients in Vientiane and visiting the hospitals as well as the only Cancer Centre in the country (10 beds for 7 million populations!). I had the opportunity to provide clinical expertise including sign/out, FNAs, consultations, and grossing as well as training the local pathologists and technical staff in the country. I am in the process of submitting a report summarizing my observations along with my recommendations for improving surgical pathology services in the country. I did the same for Botswana which led to improving their quality control and patient care in surgical pathology. The officials in Lao told me that my report will support their discussion with the ministry of health officials as well. During my meeting with the vice-president of the University Health Science as well as the Dean of medicine, they also expressed interest in more collaboration between Laos and the UBC and was asked to visit the country again. My next plan is to go and work in the periphery (rural areas), mainly FNA and Paps, where local people cannot afford traveling to the capital city Vientiane. I was also told that U of Calgary signed an MOU with them (10 years ago) in terms of providing educational support and expertise.
Alaghehbandan, Reza 2018Czech RepublicEducation and TrainingInternational INVITED SPEAKER.
Diagnosis of Renal Tumors in Core Biopsy: Clues and Pitfalls. 5th Pannonia Congress of Pathology, May 16-19, 2018, Mikulov, Czech Republic

Global research networking initiatives: This includes my work with one of the largest and prestigious GU oncologic centres in EU (Charles University, Czech Republic). We have published and presented in a collaborative fashion many papers on kidney, bladder and prostate cancers (some of which I am the first author). Below are some of my recent publications:

  • Cytopathology Feb;29(1):58-62, 2018
  • Ann Diagn Pathol Aug;35:1-6, 2018
  • Pathology Apr;50(3):369-370, 2018
  • Histopathology Apr;72(5):804-813, 2018
  • World J Urol Jun;36(6):905-911, 2018
  • Histol Histopathol 33: 277-287, 2018
  • AJSP: Reviews & Reports 2017;22: 286–289
  • Ann Diagn Pathol Aug;29:17–22, 2017
  • Int J Surg Pathol Jun;25(4):379-380, 2017
  • Ann Diagn Pathol Apr;27:48-56, 2017
  • Am J Surg Pathol Jan;41(1):138-140, 2017
  • Ann Diagn Pathol Feb;26:23–30, 2017
  • Virchows Arch 469(6):669–678, 2016
  • Ann Diagn Pathol Oct;24:7-10, 2016
  • In press (Appl Immunohistochem Mol Morphol)
  • In press (Int J Gynecol Pathol)
  • In press (Ann Diagn Pathol)
Alaghehbandan, Reza Charles University, Czech Republic2016-presentCzech RepublicResearch CollaborationGlobal research networking initiatives: This includes my work with one of the largest and prestigious GU oncologic centres in EU (Charles University, Czech Republic). We have published and presented in a collaborative fashion many papers on kidney, bladder and prostate cancers (some of which I am the first author). Below are some of my recent publications: Cytopathology Feb;29(1):58-62, 2018.
Doyle, Patrick International Society of Travel Medicine2009-2015 (PRESENT)International OtherI have been very involved in project on GeoSentinel Surveillance. I was the initial local site director, but that was taken over by Dr. Jan Hajek a couple of years ago. I am continuing to be involved in collection of cases. GeoSentineal Surveillance - Keep Reading
Dallas, Karen Indiana University, Moi Teaching and Referral Hospital2011-presentKenya Education and TrainingI was part of the Team from Indiana University (when I was at BloodCenter of Wisconsin) that went to sent up a benign Hematology program (which has since blossomed into a full fledged Hematology and Oncology program!!) in Eldoret, Kenya at Moi Teaching and Referral Hospital… it is the “second” teaching hospital/med school in the country (after Nairobi) but a city perhaps more infamous for all of the olympic-level runners who come from there! In fact there is an IOC sanctioned high altitude training facility nearby! Now, I continue to support the program mainly by sending expired or otherwise unusable (i.e. stored at a patient’s home and cannot be returned to general inventory) plasma protein products (via the I.U. Team visits) which our health care system has already paid for but which can no longer benefit Canadian patients. These expired factors (i.e. for hemophilia or immune deficiency) still work and should go to use rather than being discarded! My colleagues in the city and even across the country have supported this initiative and sent me products. And the Kenyan program has been extremely thankful.

My colleague on the ground (a Kenyan who did Hematology training at I.U.) and I also collaborate in other ways – last fall I hosted one of his top-notch clinical officers to come to Vancouver for a Transfusion Medicine course that we put on at UBC. This fall, he and I are trying to plan a Clinical Quality Improvement symposium that I would teach for local Kenyan docs.

Dallas, Karen Non profit organization based out of Portland OR2013-presentKenya OtherThere is a small non profit organization based out of Portland OR which I just “fell into”… They focus on half Education and half Medicine and travel to the slums and villages of Kenya (also Kenya – super neat story of how I met this group!!) We go once per year (with this year as an exception as they are having national election and there may be safety risks) usually in August. We bring basic supplies and medications and we hold very basic Medical camps… AND we have built a small clinic in one of the villages!! We are in the process of trying to equip a very very basic “lab” within the clinic now! J And though the basic medical clinics, you’ll meet people who need much more than we can provide so I have supported a few of my patients to have more costly specialist visits, medications, surgeries, eyeglasses, etc. I also have personally started some public health education at some of the poor schools we support – i.e. basic dental hygiene and distributing free toothbrushes. Finally, some of the kids at a small slum high school that we support – for kids with very traumatic backgrounds – I have supported them with college fees so they can become teachers themselves and give back/help their community succeed…

This non profit… though small and not highly medically specialized, it has really found a place in my heart. All the funds donated go straight to on-the-ground work. The president of the organization does not even take a salary. And I have seen people’s lives change thru our seemingly very small actions…

Aparicio, Sam Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) Canada-UK Project 2006-presentUKResearch CollaborationMolecular Taxonomy of Breast Cancer International Consortium (METABRIC) is a Canada-UK project that aims to classify breast tumours into further subcategories, based on molecular signatures that will help determine the optimal course of treatment.

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Aparicio, Sam International Cancer Genome Consortium (ICGC) Breast Cancer Working Group2009-presentInternational Research CollaborationMember, International Cancer Genome Consortium (ICGC) Breast Cancer Working Group. The ICGC was formed to coordinate a large number of research projects that have the common aim of elucidating comprehensively the genomic changes present in many forms of cancers that contribute to the burden of disease in people throughout the world.

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Aparicio, Sam Canada/CBCF 2016-2019CanadaResearch CollaborationTranslational Development of Novel Drugs Targeting Tumor Vulnerabilities; Aparicio S, Mak T; 2016-2019; SU2C Canada/CBCF; $9,000,000. Goals: Our pan-Canadian Dream Team will accelerate the development of three promising drug candidates as treatments for Triple-negative breast cancer. Our project will employ state of the art laboratory models to understand how these agents are best deployed, and then test them in clinical trials of patients with advanced breast cancer across Canada. Role: PI.
Aparicio, Sam CIHR/CEEHRC2017-2022UKResearch CollaborationCentre for Epigenome Mapping Technologies; Hirst M, Marra M, Jones S; 2017-2022; CIHR/CEEHRC; $4,050,000. Goals: To renew the CIHR Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC) Platform Centre and maintain and continue to develop the Centre for Epigenome Mapping Technologies (CEMT) Role: Co-investigator.
Aparicio, Sam Cancer Research UK2017-2023UKResearch CollaborationIMAXT, Imaging and Molecular Annotation of Xenografts and Tumours; Hannon G; 2017-2023; Cancer Research UK; $1,100,000 GBP. Goals: To develop and combine precise, 3D maps of tumours and their environment in a virtual reality experience, allowing researchers to ‘walk around’ inside a tumour, visualising how individual cells adapt to their environment. Role: Co-investigator.
Seow, Chun Chongqing Cancer Institute of Chongqing University (P. R. China)2017-presentChinaResearch Collaboration / TrainingCurrently I have ongoing collaboration with Chongqing Cancer Institute of Chongqing University (P. R. China) on projects investigating mechanisms of cell motility. Right now I am hosting a visiting scientist (Dr. Ling Ruo) from the Chongqing Cancer Institute. She started in August of 2017 in my laboratory learning basic techniques for cell mechanics and biochemistry. Her current project is on the mechanism of regulation of airway smooth muscle contractility by myosin light chain phosphorylation. Her research has resulted in a manuscript entitled “A theory governing the relationships among myosin light chain phosphorylation, shortening velocity, stiffness and power output of airway smooth muscle”, soon to be submitted. Her appointment in our department ends in Oct 31, 2018. Her salary is mostly supported by her home University in China. We plan to continue collaborating with Chongqing University and other universities in China, and through the exchange of students and visiting scientists we hope to maximize the use of resources they brought from China (both in finance and scientific expertise) for the research and training in our department.
Seow, Chun Department of Cellular and Molecular Biology, University of Texas2016-presentUSAResearch CollaborationWe are currently collaborating with Dr. Mitsuo Ikebe, Professor and Chairman of the Department of Cellular and Molecular Biology, University of Texas. We have finished one project last year, resulting in the publication of a paper in the Journal of Cell Science (Pasquale Chitano, Lu Wang, Gabrielle Y. Y. Tin, Mitsuo Ikebe, Peter D. Pare, and Chun Y. Seow. Smooth muscle function and myosin polymerization. J. Cell Sci. 130(15): 2468-2480, 2017). Our current collaboration on investigating the function of a Rho-kinase inhibitory protein p116Rip and the potential role of the protein in asthma pathophysiology. The research has resulted in a manuscript entitled: “p116Rip promotes myosin phosphatase activity in airway smooth muscle cells – A switch toward a hyper-contractile phenotype” soon to be submitted. The collaboration with Dr. Ikebe will be continuous and long term, because their biochemistry expertise complemented well with our expertise in biophysics and so far it’s been a very productive collaboration.
Hardwick, David International Academy of Pathology 2006-presentInternational OtherI have been engaged since 2006 in restructuring the International Academy of Pathology and served as Secretary from 2006 to 2014. Currently I am in a senior advisory role to the Secretary & President.

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Maurer, Elisabeth Dr. Peter vd Meer, University Medical Center Groningen2011 – presentNetherlandsResearch CollaborationPREPAReS clinical trial; Dr. Peter vd Meer, July 2011 – present; Sanquin, Leiden; A randomized controlled clinical trial to study the effectiveness of pathogen-reduced platelet concentrates in plasma, stored for up to 7 days, and compare these with untreated platelet concentrates in plasma, also stored for up to 7 days. Platelet quality and microparticle content determined with ThromboLUX were two of the in vitro characteristics used to compare the two groups. Publication in preparation. Keep Reading
Maurer, Elisabeth Cedars-Sinai Los Angeles; Dr. Ellen Klapper2017 – presentAustriaResearch Collaboration Platelet inventory management quality initiative based on microparticle screening; May 2017 – present; Cedars-Sinai Los Angeles; Dr. Ellen Klapper; Evaluation of platelet inventory management based on microparticle screening conducted at a large hospital blood bank to reduce the risk of new patients becoming platelet refractory. Specifically, refractoriness from “non-immune” sources are expected to be mitigated. This was done by characterizing platelets by microparticle content and directing them to specific patient groups based on this characterization. The initial 4 months evaluation was conducted as a non-IRB quality improvement initiative.; Interim results were shared: Cedars Sinai reduced the number of refractory patients from an average 2.5 to 1 which reduced the number of platelet transfusions required by 98 over the 4 months period. This is a significant improvement in patient care. Data will be presented at AABB in Oct. An abstract was submitted for presentation at AABB2018.
Maurer, Elisabeth Univeristy of California, Davis (UCD); Dr. Sara Barnhard;2018 – presentUSAResearch CollaborationPlatelet inventory management quality initiative based on microparticle screening; Aug 27 – present; Univeristy of California, Davis (UCD); Dr. Sara Barnhard; Evaluation of platelet inventory management based on microparticle screening conducted at a large hospital blood bank to reduce the risk of new patients becoming platelet refractory. Specifically, refractoriness from “non-immune” sources are expected to be mitigated. This was done by characterizing platelets by microparticle content and directing them to specific patient groups based on this characterization.; Testing has just started. This study had been stopped due to resource limitations.
Maurer, Elisabeth Duke University Hospital School of Medicine (PI: Dr. Jessica Poisson)2018USAResearch CollaborationPlatelet inventory management quality initiative based on microparticle screening
Maurer, Elisabeth University of Colorado Denver (PI Dr. Joel Kniep)2018USAResearch CollaborationPlatelet inventory management quality initiative based on microparticle screening
Maurer, Elisabeth Children's Medical Center Dallas (PI Dr. Daniel Noland)2018USAResearch CollaborationPlatelet inventory management quality initiative based on microparticle screening
Maurer, Elisabeth University of Kansas Medical Center (PI Dr. Zhan Ye)2018USAResearch CollaborationPlatelet inventory management quality initiative based on microparticle screening
Maurer, Elisabeth Rigshospital, Copenhagen2013-2015DenmarkResearch CollaborationMicroparticle testing of platelet donors and products; Sept 2013 – May 2015; Rigshospital, Copenhagen; In circulation, shedding of microparticles from a variety of viable cells can be triggered by pathological activation of inflammatory processes, by activation of coagulation or complement systems, or by physical stress. Elevated microparticle content (MPC) in donor blood might therefore indicate a clinical condition of the donor which, upon transfusion, might affect the recipient. In blood products, elevated MPC might also represent product stress. Surprisingly, the MPC in blood collected from normal blood donors is highly variable, which raises the question whether donor microparticles are present in-vivo and transfer into the final blood component, and how production methods and post-production processing might affect the MPC. We measured MPC using ThromboLUX in (a) platelet-rich plasma (PRP) of 54 apheresis donors and the corresponding apheresis products; Maurer-Spurej, E., et al. (2016). "Microparticle content of platelet concentrates is predicted by donor microparticles and is altered by production methods and stress." Transfus Apher Sci 55(1): 35-43.
Maurer, Elisabeth North Shore Long Island Jewish Hospital (NSLIJ), New York; Dr. Andrew Heaton2014-2015USAResearch Collaboration Blinded study on consecutive transfusable platelet products tested with the ThromboLUX® platelet quality test; July 2014 – Aug 2015; North Shore Long Island Jewish Hospital (NSLIJ), New York; Dr. Andrew Heaton; Blinded study on consecutive transfusable platelet products tested with the ThromboLUX® platelet quality test. This study is conducted in the United States. The aim of the study is to:
  • Evaluate the safety and effectiveness of ThromboLUX for its use in providing information regarding the quality of platelet components with a quantitative result (TLX Score)
  • Investigate the agreement between the TLX Score and clinical transfusion outcome measured as 1-hour corrected count increment (1hr CCI) in hematology-oncology outpatients
  • The study population will consist of adults who require platelet transfusions in accordance with normal clinical practice
  • Clinical performance evaluation of the ThromboLUX platelet quality test
  • Study IDs
  • Pre-Sub for Study – CRMTS #8750 Ref # PS000890 Supplement

Maurer-Spurej, E., et al. (2016). "Microparticle content of platelet concentrates is predicted by donor microparticles and is altered by production methods and stress." Transfus Apher Sci 55(1): 35-43. A new study is in the planning phase now.
Maurer, Elisabeth Banner - University Medical Center Tucson (BUMCT),Arizona2015-2016USAResearch Collaboration Platelet inventory management quality initiative based on microparticle screening; Oct 2015 – March 2016; Banner University Medical Center Tucson (BUMCT); Dr. Maria Proytcheva; The Evaluation was conducted with three phases: Obtain the historic platelet per patient average per month (the “Baseline”); Prospective data collection for 3 months (the “Intervention”); Determine Baseline minus Intervention (the “Savings”)
    Objectives:
  • Implement ThromboLUX for screening of platelet bags which enables the user to direct homogeneous platelets to prophylactic use and heterogeneous platelets to therapeutic use to optimize available inventory
  • Improve patient care and drive cost efficiencies by preventing platelet refractoriness. Success of this objective is indicated by a reduction in platelets per patient of 5% or more. The evaluation resulted in an overall reduction in platelet use at the hospital of 6.5%
Maurer, Elisabeth University of Maryland; Dr. Magali Fontaine2017USAResearch Collaboration Platelet inventory management quality initiative based on microparticle screening; Oct 2017; University of Maryland; Dr. Magali Fontaine; Evaluation of platelet inventory management based on microparticle screening conducted at a large hospital blood bank to reduce the risk of new patients becoming platelet refractory. Specifically, refractoriness from “non-immune” sources are expected to be mitigated. This was done by characterizing platelets by microparticle content and directing them to specific patient groups based on this characterization. Has not started yet.
Maurer, Elisabeth Memorial Sloan Kettering (MSK) New York; Dr. Ellinor Peerschke2017USAResearch CollaborationMicroparticles as predictors of sepsis; Nov 2017; Memorial Sloan Kettering (MSK) New York; Dr. Ellinor Peerschke; Prediction of sepsis - a protocol is underway at MSK and microparticle screening could be added to it. The samples are leftovers from the CBC (EDTA-antocoagulated whole blood) which will be centrifuged for PRP to be tested with the ThromboLUX microparticle assay. PRP cpi;d be fixed 1:1 with 4% Paraformaldehyde (PFA, commercially available as 4% solution in PBS https://www.alfa.com/en/catalog/J61899/ ) The goal is to determine whether MP could be predictive of sepsis and correlate with other markers of sepsis. Do you think slide 4 speaks to that? Number of patients per year to be determined. This study has not started yet because the lab has moved which took longer than expected and a new faculty member has joined who will take on the project.
Maurer, Elisabeth University of Southern California (USC), Los Angeles; Dr. Ira Shulman2017USAResearch Collaboration Microparticle testing to confirm heparin-induced thrombocytopenia (HIT); Nov 2017; University of Southern California (USC), Los Angeles; Dr. Ira Shulman; This prospective observational cohort study will be conducted at the University of Southern California.
  • The primary objective is to investigate if microparticle content (%MP) detected by dynamic light scattering (DLS) in samples of sensitive donor platelets mixed with patient plasma can confirm heparin-induced thrombocytopenia (HIT) compared to the current confirmatory assays (HIT antibody ELISA and serotonin release assay (SRA)). The hypothesis is that microparticle testing is not inferior to current confirmatory tests.
  • The study population will be cardiac surgery patients planned to receive heparin.
  • This observational study does not require any additional patient intervention or deviation from standard of care. Four samples will be obtained from either left-over CBC or ELISA testing samples and measured on ThromboLUX for %MP. The results will be compared to the current HIT confirmation tests 4T, ELISA and SRA tests.
  • Four samples for ThromboLUX testing:
    1. neat patient serum
    2. donor platelets: in PRP (A) or washed with Tyrode’s buffer (B)
    3. donor platelets + patient serum
    4. donor platelets + patient serum + heparin
USC does not have enough donors to conduct assay development. I am working with Dr. Brian Curtis at BloodCenter of Wisconsin to conduct this study. Alternatively, I also have an offer to work with Dr. Ishac Nazy at McMaster in Hamilton. A feasibility study is planned to start in July 2018.
Wellington, Cheryl International Traumatic Brain Injury Research Consortium2017-presentInternationalResearch CollaborationScientist in the International Traumatic Brain Injury Research Consortium with leadership roles in the Biomarkers Working Group.
Wellington, Cheryl Pfizer2016-presentUSAResearch CollaborationSponsored research collaboration (funded) with Pfizer on Traumatic Brain Injury.
Wellington, Cheryl AstraZeneca (Sweden) Sponsored Research2015-2016SwedenResearch CollaborationSponsored research collaboration (no-cost extension phase) with AstraZeneca on ApoE modulators.
Wellington, Cheryl Cure Alzheimer Fund2017-2019USAResearch CollaborationResearch grant with Cure Alzheimer Fund, with USA investigators David Holtzman, Guojun Bu, Oleg Butovsky and Randall Bateman.
Wellington, Cheryl Rice University, Dr. Jordan Miller2018-presentUSAResearch CollaborationResearch collaboration (not yet funded) with Jordan Miller (Rice University) on tissue engineering.
Wellington, Cheryl UPMC Children's Hospital of Pittsburgh, Dr. Rachel Berger2018-presentUSAResearch CollaborationResearch collaboration (not yet funded) with Rachel Berger on Traumatic Brain Injury.
Wellington, Cheryl The Sport Science Center at TCU, dr. Jonathan Oliver2018-presentUSAResearch Collaboration Research collaboration (funded) with Jonathan Oliver on concussion.
Myles, Nickolas Russian Edition of Testing Treatments: Better research for Better Healthcare by Imogen Evans, Hazel Thornton, Iain Chalmers, Paul Glasziou2018-presentRussiaEducation and TrainingI am engaged as a volunteer medical scientific translator / editor of Russian Edition of Testing Treatments: Better research for Better Healthcare by Imogen Evans, Hazel Thornton, Iain Chalmers, Paul Glasziou. This book is a highly regarded educational resource for everybody who wants to know how treatment claims work in the world of Evidence-Based Medicine. It has now been translated into 14 languages in addition to already two highly successful English editions, and now includes all official languages of the United Nations. Keep Reading
Nielsen, TorstenDanish Breast Cancer group2011-presentDenmarkResearch CollaborationOngoing multiple collaborative research programs with the Danish Breast Cancer group, including recent publications (PMIDs 27601592 29168407 29172851 29202609) and active MTAs -- all to do with breast cancer biomarker development. Update: additional major publication relating to the application of Canadian biomarker technology onto Danish clinical trials: PMID 29369732. Analysis – Scandinavian clinical trial participation and specimen collection is best in the world, but genomic technology is not at the same level. This collaboration allows symbiotic acceleration of formal demonstration of clinical validity for new breast cancer tests. Related project currently being activated with a group from Finland.
Nielsen, TorstenKarolinska Institute in Sweden2017-presentSwedenResearch CollaborationCollaborative Grant funding for sarcoma research with a subcontract to a research at the Karolinska in Sweden - active research program in synovial sarcoma. Update: new grant application through US NIH involving a collaborator based in Heidelberg, Germany, to study synovial sarcoma.
Nielsen, TorstenUK, Germany, India and Lithuania, previous: Japan, France, Italy, Denmark, Sweden, Belgium2015-presentInternational Research CollaborationLeading an international research team on standardizing Ki67 testing in breast cancer. Manuscript being resubmitted includes coauthors from UK, Germany, India and Lithuania; previous publications included also Japan, France, Italy, Denmark, Sweden, Belgium.
Nielsen, TorstenAustralia, Belgium, Germany, Italy, France and Spain.International Research CollaborationParticipating as an executive member in an international team seeking to standardize immunooncology biomarker assessment in breast cancer, involving Australia, Belgium, Germany, Italy, France and Spain. Update: group is now also addressing artificial neural network / deep learning technology.
Nielsen, TorstenKorean National Cancer Centre, Hong Kong, Osaka and Kyoto2017-presentInternational Education and TrainingerInvited keynote speaker for Korean National Cancer Centre (June 2017) and for a workshop in Hong Kong (January 2018), both involving research and CME activities. Update: invited also to keynote sessions in Osaka and Kyoto
Bradley, Amanda BMLSc-faculty/staff run a UBC Faculty of Medicine Vancouver Summer Program (VSP) Package for international students2016-presentInternational Education and TrainingEducational international activities:

BMLSc-faculty/staff run a UBC Faculty of Medicine Vancouver Summer Program (VSP) Package for international students. The name of our VSP package is Medical Laboratory Science. In July, 2018 we will be teaching this 2-course package for the third time.

FOM VSP coordinator, Katya Leonardia - katya.leonardia@ubc.ca

I will briefly add some pertinent information specific to the Medical Laboratory VSP package.
  • Information about currency of the projects: International students pay their tuition in Canadian currency
  • Time lines to completion: our 2 courses are run/taught from mid-July to mid-August, annually since July 2016; the teaching/design team meet annually to revisit and improve the courses
  • Outcome of the completed projects. VSP international student cohorts complete the 2 courses. It is up to their individual home universities to determine whether the students receive credit at their institution for completing our courses. International students experience Vancouver culture including the culture of teaching and learning here at UBC
  • Scalability of projects: Because we have a large hands-on laboratory component to our courses, our max student intake is ~ 36. We increased our max from 30 to 36
  • Plans for the future: Plan to run the package again in the summer of 2019/20. We may then take a break for a year as teaching these courses summer after summer is likely not sustainable for our laboratory staff.
  • Information about lessons learned: Likely these are shared with other Faculty of Medicine VSP packages. Lessons include trying to support students with variable degrees of comfort with English and with different educational backgrounds as well as recognizing the cultural differences with respect to educational interactions. We have become much more clear and transparent up front about our expectations for interactivity in the class and we explain the pedagogies used, including describing some of the evidence to support our teaching methods. We ensure a safe environment so that international students can attempt interactions without fear of judgement.
  • What supportive systems are required maximising the positive outcomes: We spend class time addressing differences in culture and expectations; we works with the international students to co-create ground rules. We ask them for feedback part-way through and can make some changes mid-package. We try to scaffold experiences so that students are challenged just enough and supported just enough. We get feedback from some students that they didn’t find the courses challenging enough and feedback from others that it was just right (enough outside their comfort zone to be doable and give them a sense of achievement).
Goldfarb, David University of Botswana, Botswana National Health Laboratory, Botswana University of Pennsylvania, Cambridge University and CDC Atlanta2014-presentBotswana Research Collaboration Botswana collaboration – longstanding collaboration with numerous partners in Botswana and elsewhere including at the University of Botswana, Botswana National Health Laboratory, Botswana University of Pennsylvania, Cambridge University and CDC Atlanta. I previously was faculty at the University of Botswana (2009 – 2014). My work there has focussed on education, building laboratory capacity and clinical research. I have secured over $1M USD in research funding as either PI or co-PI. Primary focus of research has been childhood diarrheal disease and evaluation of infectious disease diagnostics. Have now had over 15 peer reviewed publications from this collaboration and I have been involved in national immunization and antimicrobial use policy making and our work has been featured in numerous media including the NY Times .
Goldfarb, David Clinical and Public Health Partners2007-presentNunavutResearch CollaborationNunavut – long standing collaboration with clinical and public health partners, focusing specifically on improving understanding of enteric infections in the region and improving infectious disease diagnostics in the territory. Recently invited by Government of Nunavut and Inuit Tapiriit Kanatami (ITK) to National TB Expert Meeting to develop a strategy for TB elimination in the Inuit.
Goldfarb, David Malawi College of Medicine2015-presentMalawiResearch CollaborationMalawi College of Medicine – am co-PI on an IDRC funded project based in Blantyre and surrounding districts that aims to better understand barriers and facilitators to implementation of a neonatal care package at the district level ( https://www.idrc.ca/en/project/integrating-neonatal-healthcare-package-malawi-imcha-0 ).
Goldfarb, David World Health Organization2017-presentInternationalEducation and TrainingWHO – invited by WHO Essential Medicines and Health Products to serve as expert consultant on their Technical Specifications Series for submission to WHO Prequalification – Cholera Rapid Diagnostic Test ( http://www.who.int/diagnostics_laboratory/guidance/171109_tss5_draft_rdts_used_for_surveillance_detection_of_cholera_outbreak.pdf?ua=1 )
Goldfarb, David McGill Global Health Diagnostics Course2016-presentInternational Education and TrainingMcGill Global Health Diagnostics Course – have served as invited faculty member 2016, 2017, 2018 ( http://mcgill-idgh.ca/courses/global-health-diagnostics/ )
Orde, MatthewNational Centre of Forensic Medicine, Tel-Aviv, Israel2018-presentIsraelEducation and TrainingExternal residency forensic pathology examiner, National Centre of Forensic Medicine, Tel-Aviv, Israel
Orde, MatthewUniversity of Cape Town, South Africa2017-presentSouth AfricaEducation and Training External residency forensic pathology examiner, University of Cape Town, Republic of South Africa
Orde, MatthewFiji National University2017-presentFijiEducation and TrainingAd-hoc lecturer in forensic pathology, Fiji National University