Blake is a Professor Emeritus in the Dept of Pathology and Laboratory Medicine, at the University of British Columbia. He leads a research program focused on gynecological cancers. He was lead pathologist on studies refining the histotype-based classification of ovarian carcinoma, molecular classification of endometrial carcinoma, and etiology-based classification of vulvar carcinoma, and was part of the team that championed opportunistic salpingectomy to prevent tubo-ovarian high grade serous carcinoma. He has been an author on more than 500 peer-reviewed publications, with more than 40,000 citations. He is co-founder and medical-director of the Canadian Pathology Quality Assurance program, which provides proficiency testing for Canadian diagnostic immunohistochemistry laboratories.