Mackenzie, Ian

Mackenzie, Ian


Academic Rank(s): Professor, Department of Pathology & Laboratory Medicine, Faculty of Medicine, UBC | Consultant Neuropathologist at Vancouver Acute and BC Cancer Agency

Affiliation(s): VGH & Djavad Mowafaghian Centre for Brain Health

Research and Scholarly Interests: Dementia, frontotemporal dementia, amyotrophic lateral sclerosis, neurodegenerative disease, proteinopathy, molecular genetics

Clinical Interests: neuropathology, focusing on the use of brain tissue in various clinical contexts

Short Bio

Dr. Ian MacKenzie is a Professor in the Department of Pathology and Laboratory Medicine at the University of British Columbia (UBC). He also serves as a Consultant Neuropathologist at Vancouver Acute and BC Cancer Agency and is the Head of Neuropathology at Vancouver General Hospital. His academic and professional journey includes significant expertise in neuropathology and the use of brain tissue banks for patients with neurological disorders. Dr. MacKenzie’s research focuses on the molecular genetics of neurodegenerative diseases, particularly dementias, and he is involved in various neuropathology journals and international societies​ (Pathology)​​ (centreforbrainhealth)​​ (Pathology)​.


Academic Background

  • Certificate of the Royal College of Physicians and Surgeons of Canada (FRCPC) Neuropathology. 1989
  • MD, University of Western Ontario, London, Medicine. 1984
  • University of Western Ontario, London, Chemistry (Honours). 1980

Awards and Recognition





Research Interest

Dr. Ian Mackenzie, a neuropathologist, has extensive expertise in using brain tissue banks in the care of patients with neurological disorders. His research program centres on neuropathology and the molecular genetics of neurodegenerative disease, particularly dementias. He leads the program on FTD that has resulted in the discovery of several gene mutations that cause this disease. Specifically, Drs. Mackenzie and Hsiung, along with collaborators from the Mayo Clinic and the University of California, San Francisco, are investigating a common genetic mutation underlying amyotrophic lateral sclerosis and a form of dementia helps to explain why many patients with those diseases get symptoms of the other. This finding was significant because the implications of finding the common genetic mutation to two diseases may lead to a treatment that could be used for both.

Current Projects In My Lab Include


Teaching Interest

Dr. Luo is actively involved in graduate-level teaching.