Academic Rank:
Clinical Assistant Professor, UBC
Affiliation(s):
Surrey Memorial Hospital
Royal Columbian Hospital

Academic background

  • Fellow of the Canadian Association of Clinical Biochemists (FCACB), 2017
  • PhD Dalhousie University 2014
  • BSc Microbiology/Immunology and Biochemistry/ Molecular Biology Dalhousie University 2009

Awards and Recognition

• Canadian Society for Mass Spectrometry “Best Thesis Involving Mass Spectrometry” award, 2015

Publications

  • Leung, A.A.; Orton, D.J.; Chin, A.; Sadrzadeh, S.M.H.; Kline, G.A. (2017) A Novel Approach to Establishing an Aldosterone:Renin Ratio Cutoff for Primary Aldosteronism. Hypertension. [Published Jan. 9, 2017]. Doi HYPERTENSIONAHA.116.08407.
  • Orton, D.J.; Gifford, J.L.; Seiden-Long, I.; Khan, A.; de Koning, L. (2016) Critically-high plasma ammonia in an adolescent. Clin. Chem. 62(12):1565-69.
  • Goswami, I.; Orton, D.J.; Rabi, Y.; Seiden-Long, I. (submitted) Preterm infant with brown plasma. Clin. Biochem. Apr. 2016.
  • Orton, D.J.; Naugler, C.; Sadrzadeh, S.M.H. (2016) Fasting time and Vitamin B12 levels in a community-based population. Clin. Chim Acta. 458:129-32.
  • Orton, D.J.; Boyd, J.M.; Affleck, D.; Walsh, W.; Duce, D.; Seiden-Long, I. (2016) One-step extraction and quantitation of toxic alcohols and ethylene glycol in plasma by capillary gas chromatography (GC) with flame ionization detection (FID). Clin. Biochem. 49(1):132-8.
  • Orton, D.J.; Baskin, L.B. (2015) Spuriously Elevated Cyclosporine in a Patient with an Indwelling Central Line. ASCP Case Reports. December 28, 2015
  • Orton, D.J., Doucette, A.A., Huang, W.Y., MacLellan, D.L. (submitted) Exosomal proteomic analysis reveals changes in the urinary proteome of rats with unilateral ureteral obstruction. Biochim. Biophys. Acta Mar. 16, 2015.
  • Doucette, A.A., Vieira, D.B., Orton, D.J., Wall, M.J. (2014) Resolubilization of precipitated intact membrane proteins with cold formic acid for analysis by mass spectrometry. J. Proteome Res. 13(12):6001-12.
    Orton, D.J., Doucette, A.A., Maksym, G.N., MacLellan, D.L. (2013) Proteomic analysis of rat proximal tubule cells following stretch-induced apoptosis in an in vitro model of kidney obstruction. J. Proteomics 100:125-35.
    Orton, D.J., Wall, M.J., Doucette, A.A. (2013) A dual LC/MS platform for high throughput proteome analysis. J. Proteome Res. 12(12):5963-70.
    Orton, D.J., Doucette, A.A. (2013) Proteomic workflows for biomarker identification – technical and statistical considerations during initial discovery. Proteomes 1:109-127.
    Orton, D.J., Arsenault, D.J., Thomas, N.A., Doucette, A.A. (2013) GELFrEE fractionation combined with mass spectrometry for proteome analysis of secreted toxins from Enteropathogenic Escherichia coli (EPEC). Mol. Cell. Probes. 27(5-6):200-7
    Orton, D.J., Doucette, A.A. (2013) A universal, high recovery assay for protein quantitation through temperature programmed liquid chromatography (TPLC). J. Chromatogr. B Analyt Technol. Biomed. Life Sci. 15(921-22):75-80.
    Nasrallah, G.K., Gagnon, E., Orton, D.J., Garduno, R.A. (2011) The htpAB operon of Legionella pneumophila cannot be deleted in the presence of the groE chaperonin operon of Escherichia coli. Can. J. Micobiol. 57(11):943-52

Research Interest

• Blood research
• Clinical Applied Research
• Endocrinology, Metabolism & Nutrition
• Genetics genomics proteomics and related approaches
• Informatics

Teaching Interest

• Path 406/407