Enfield, Katey
PhD
Academic Rank(s): Assistant Professor, Department of Pathology and Laboratory Medicine, Faculty of Medicine, UBC; Scientist in the Department of Basic and Translational Research at the BC Cancer Research Institute
Affiliation(s): BC Cancer Research Institute
Research and Scholarly Interests: lung cancer, tumour microenvironment, cancer immunology, cancer genomics, B cells, spatial profiling techniques, bioinformatics
Dr. Enfield is an Assistant Professor in the Department of Pathology and Laboratory Medicine at the University of British Columbia (UBC), and a Scientist in the Integrative Oncology department at the BC Cancer Research Institute (BCCRI). Dr. Enfield’s lab is located at BCCRI and is embedded within the collaborative PRO-Lung research network of scientists and clinicians.
Dr. Enfield grew up in British Columbia and received her BSc in Microbiology from the University of Victoria. She then moved to Vancouver and completed her PhD at UBC under the supervision of Dr. Wan Lam, where she employed a multi-omics approach to discover and characterize oncogenes and tumour suppressor genes in lung cancer.
Dr. Enfield undertook a postdoctoral fellowship at the Francis Crick Institute in London, UK, in Professor Charles Swanton’s Cancer Evolution and Genome Instability Lab. There, she studied the reciprocal relationships between cancer-intrinsic genomic alterations and the immune response as part of the TRACERx lung cancer study.
Dr. Enfield has expertise in highly multiplexed spatial profiling of the lung tumour microenvironment and in the integration of genomic and immunological data. Her lab uses these approaches to improve understanding of the immune response to lung cancer and the reasons for success or failure of immunotherapies.
Affiliations
Assistant Professor, Pathology and Laboratory Medicine, University of British Columbia
Scientist, Basic and Translational Research, BC Cancer Research Institute
Visiting Scientist, Francis Crick Institute
Follow
X: https://x.com/EnfieldKatey
LinkedIn: https://www.linkedin.com/in/katey-enfield-a5109665/
Bluesky: https://bsky.app/profile/kateyenfield.bsky.social
Academic Background
- Postdoctoral Fellowship, Cancer Evolution and Genome Instability Laboratory, Francis Crick Institute, London, UK, 2018-2024
- PhD, Interdisciplinary Oncology Program, University of British Columbia, 2010-2017
- BSc, Microbiology, University of Victoria, 2005-2009
Awards and Recognition
- Marie Skłodowska-Curie Actions Individual Fellowship, Horizon Europe, 2019-2021
- Betty Rice Award for Research Excellence in Lung Cancer, Canada, 2018
- AACR Scholar-in-Training Award, AACR-IASLC Lung Cancer Translational Science from the Bench to the Clinic, USA, 2018
- Lloyd Skarsgard Research Excellence Prize, BCCRI, 2017
- Young Investigator Award, IASLC 18th Conference of Lung Cancer, Japan, 2017
- Adi Gazdar Lectureship Award, IASLC 18th Conference of Lung Cancer, Japan, 2017
- Four Year Doctoral Fellowship, UBC, 2012-2016
Publications
Dr. Katey Enfield (Google Scholar)
Selected Publications
- Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer.
Enfield KSS*, Colliver E*, Lee C*, Magness A*, Moore DA, Sivakumar M, Grigoriadis K, Pich O, Karasaki T, Hobson PS, Levi D, Veeriah S, Puttick C, Nye EL, Green M, Dijkstra KK, Shimato M, Akarca AU, Marafioti T, Salgado R, Hackshaw A; TRACERx consortium; Jamal-Hanjani M, van Maldegem F, McGranahan N, Glass B, Pulaski H, Walk E, Reading JL, Quezada SA, Hiley CT, Downward J, Sahai E, Swanton C, Angelova M. Cancer Discov. 2024 Jun 3;14(6):1018-1047. doi: 10.1158/2159-8290.CD-23-1380. - Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX.
Magness A*, Colliver E*, Enfield KSS*, Lee C, Shimato M, Daly E, Moore DA, Sivakumar M, Valand K, Levi D, Hiley CT, Hobson PS, van Maldegem F, Reading JL, Quezada SA, Downward J, Sahai E, Swanton C, Angelova M. Nat Commun. 2024 Jun 15;15(1):5135. doi: 10.1038/s41467-024-48870-5. - Antibodies against endogenous retroviruses promote lung cancer immunotherapy.
Ng KW*, Boumelha J*, Enfield KSS*, Almagro J, Cha H, Pich O, Karasaki T, Moore DA, Salgado R, Sivakumar M, Young G, Molina-Arcas M, de Carné Trécesson S, Anastasiou P, Fendler A, Au L, Shepherd STC, Martínez-Ruiz C, Puttick C, Black JRM, Watkins TBK, Kim H, Shim S, Faulkner N, Attig J, Veeriah S, Magno N, Ward S, Frankell AM, Al Bakir M, Lim EL, Hill MS, Wilson GA, Cook DE, Birkbak NJ, Behrens A, Yousaf N, Popat S, Hackshaw A; TRACERx Consortium; CAPTURE Consortium; Hiley CT, Litchfield K, McGranahan N, Jamal-Hanjani M, Larkin J, Lee SH, Turajlic S, Swanton C, Downward J, Kassiotis G. Nature. 2023 Apr;616(7957):563-573. doi: 10.1038/s41586-023-05771-9. - Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma.
Enfield KSS, Marshall EA, Anderson C, Ng KW, Rahmati S, Xu Z, Fuller M, Milne K, Lu D, Shi R, Rowbotham DA, Becker-Santos DD, Johnson FD, English JC, MacAulay CE, Lam S, Lockwood WW, Chari R, Karsan A, Jurisica I, Lam WL. Nat Commun. 2019 Nov 28;10(1):5438. doi: 10.1038/s41467-019-13295-y. - Hyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrence.
Enfield KSS, Martin SD, Marshall EA, Kung SHY, Gallagher P, Milne K, Chen Z, Nelson BH, Lam S, English JC, MacAulay CE, Lam WL, Guillaud M. J Immunother Cancer. 2019 Jan 16;7(1):13. doi: 10.1186/s40425-018-0488-6. - Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome.
Enfield KS, Martinez VD, Marshall EA, Stewart GL, Kung SH, Enterina JR, Lam WL. Oncotarget. 2016 Dec 6;7(49):80957-80966. doi: 10.18632/oncotarget.13133. - EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk.
Wilson IM*, Vucic EA*, Enfield KS, Thu KL, Zhang YA, Chari R, Lockwood WW, Radulovich N, Starczynowski DT, Banáth JP, Zhang M, Pusic A, Fuller M, Lonergan KM, Rowbotham D, Yee J, English JC, Buys TP, Selamat SA, Laird-Offringa IA, Liu P, Anderson M, You M, Tsao MS, Brown CJ, Bennewith KL, MacAulay CE, Karsan A, Gazdar AF, Lam S, Lam WL. Oncogene. 2014 Sep 4;33(36):4464-73. doi: 10.1038/onc.2013.396. - MicroRNA gene dosage alterations and drug response in lung cancer.
Enfield KS, Stewart GL, Pikor LA, Alvarez CE, Lam S, Lam WL, Chari R. J Biomed Biotechnol. 2011;2011:474632. doi: 10.1155/2011/474632.
Research Interest
The Enfield Lab is interested in the immune response to lung cancer, with a focus on profiling methods that retain spatial information.
- Spatial organisation of the lung tumour microenvironment and associations with clinical outcomes
- B cell responses to lung cancer, including mechanisms underlying their associations with immunotherapy response
Recruitment
Teaching Interest
- MEDG 521 / PATH 531 – Course Co-ordinator
- ONCO 548B – Course Instructor
- ONCO 502 – Guest Lecturer
- ONCO 510 – Evaluator
- MEDG 421 – Guest Lecturer