Professor
work phone: 604-875-4111
Location
Vancouver General Hospital
Dr. Mackenzie is Professor of Pathology and Laboratory Medicine at The University of British Columbia, Consultant Neuropathologist of Vancouver Acute and BC Cancer Agency, and Head of the Neuropathology Division at Vancouver Acute.
Dr. Mackenzie has broad expertise in neuropathology and the use of brain tissue banks in the care of patients with neurological disorders. His research program centers on neuropathology and the molecular genetics of neurodegenerative disease, particularly dementias. He is currently the Canadian representative to the International Society of Neuropathology and is an editorial board member for a number of neuropathology journals.
Academic background
- University of Western Ontario, London, Chemistry (Honours). 1980
- MD, University of Western Ontario, London, Medicine. 1984
- Certificate of the Royal College of Physicians and Surgeons of Canada (FRCPC) Neuropathology. 1989
Research Interest
- Neuroscience
- Aging and Neurodegenerative Disease
- Neuro-oncology
- Molecular Pathology
Publications
- Mackenzie IR, Munoz DG, Kusaka H, Yokota O, Ishihara K, Roeber S, Kretzschmar HA, Cairns NJ, Neumann M. Distinct pathological subtypes of FTLD-FUS. Acta Neuropathol. 2011 Feb;121(2):207-218.
- Hsiung GY, Fok A, Feldman HH, Rademakers R, Mackenzie IR. rs5848 polymorphism and serum progranulin level. J Neurol Sci. 2011 Jan 15;300(1-2):28-32.
- Mackenzie IR, Rademakers R, Neumann M. TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol. 2010 Oct;9(10):995-1007. Review.
- Woulfe J, Gray DA, Mackenzie IR. FUS-immunoreactive intranuclear inclusions in neurodegenerative disease.Brain Pathol. 2010 May;20(3):589-97.
- Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, Ince PG, Kamphorst W, Revesz T, Rozemuller AJ, Kumar-Singh S, Akiyama H, Baborie A, Spina S, Dickson DW, Trojanowski JQ, Mann DM. Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol. 2009 Jan;117(1):15-8.
- Mackenzie IR, Rademakers R. The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia. Curr Opin Neurol. 2008 Dec;21(6):693-700.
- Mackenzie IR, Foti D, Woulfe J, Hurwitz TA. Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions. Brain. 2008 May;131(Pt 5):1282-93.
- Mackenzie IR. The neuropathology of FTD associated With ALS. Alzheimer Dis Assoc Disord. 2007 Oct-Dec;21(4):S44-9.
- Mackenzie IR, Rademakers R. The molecular genetics and neuropathology of frontotemporal lobar degeneration: recent developments. Neurogenetics. 2007 Nov;8(4):237-48.
