Academic Rank:
Professor, UBC
Staff Neuropathologist, Vancouver Coastal Health
Consultant Neuropathologist, BC Cancer Agency
Vancouver General Hospital

Dr. Mackenzie is Professor of Pathology and Laboratory Medicine at The University of British Columbia, Consultant Neuropathologist of Vancouver Acute and BC Cancer Agency, and Head of the Neuropathology Division at Vancouver Acute.

Dr. Mackenzie has broad expertise in neuropathology and the use of brain tissue banks in the care of patients with neurological disorders. His research program centers on neuropathology and the molecular genetics of neurodegenerative disease, particularly dementias. He is currently the Canadian representative to the International Society of Neuropathology and is an editorial board member for a number of neuropathology journals.

Academic background

  • Certificate of the Royal College of Physicians and Surgeons of Canada (FRCPC) Neuropathology. 1989
  • MD, University of Western Ontario, London, Medicine. 1984
  • University of Western Ontario, London, Chemistry (Honours). 1980


  • Riedl L, Mackenzie I, Förstl H, Kurz A, Diehl-Schmid J. Frontotemporal lobar degeneration: Current perspectives. Neuropsychiatric Disease and TreatmentNeuropsychiatr Dis Treat 2014; 10: 297-310.
  • Proudfoot M, Gutowski NJ, Edbauer D, Hilton DA, Stephens M, Rankin J, Mackenzie IR. Early dipeptide repeat pathology in a frontotemporal dementia kindred with C9ORF72 mutation and intellectual disability. Acta Neuropathol 2014; 127: 451-458.
  • Grad LI, Yerbury JJ, Turner BJ, Guest WC, Pokrishevsky E, O’Neill MA, Yanai A, Silverman JM, Zeineddine R, Corcoran L, Kumita JR, Luheshi L, Yousefi M, Coleman BM, Hill AF, Plotkin SS, Mackenzie IR, Cashman NR. Intercellular propagated misfolding of wild-type Cu-Zn superoxide dismutase: Implications for amyotrophic lateral sclerosis. PNAS 2014; 111: 3620-3625.
  • Hallam BJ, Jacova C, Hsiung RGY, Wittenberg D, Sengdy P, Bouchard-Kerr P, Slack P, Rademakers R, Baker M, Chow TW, Levine B, Feldman HH, Mackenzie IR. Early neuropsychological characteristics of progranulin mutation carriers. J Int Neuropsychol Soc 2014; 20: 1-10.
  • Mackenzie IRA, Frick P, Neumann M. The neuropathology associated with repeat expansions in the C9ORF72 gene. Acta Neuropathol 2014; 127: 347-357.
  • Lee WC, Almeida S, Prudencio M, Caulfield TR, Zhang YJ, Tay WM, Bauer P, Chew J, Sasaguri H, Jansen-West KR, Gendron TF, Stetler CT, Finch N, Mackenzie IR, Rademakers R, Gao FB, Petrucelli L. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet 2014; 15:1467-1478.
  • Armstrong RA, Hamilton RL, Mackenzie IRA, Hedreen J, Cairns NJ. Laminar distribution of the pathological changes in sporadic cases of frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study using polynomial curving fit. Neuropathol Appl Neurobiol 2013; 36: 335-347.
  • Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt B, Lamb B, Grether M, Knopman D, Cairns N, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian Z, Sutherland M, Farese R, Miller BL, Cummings J. Frontotemporal degeneration: The Next Therapeutic Frontier: Molecules and animal models for FTD drug development (Part 1 of 2 articles). Alzheimers Dement 2013; 9: 176-188.

Research Interest

  • Neuroscience
  • Aging and Neurodegenerative Disease
  • Neuro-oncology
  • Molecular Pathology