Academic Rank:
Clinical Professor, UBC
Head and Medical Director, Dept of Pathology, Children’s & Women’s Health Centre of British Columbia
Affiliation(s):
BCCH/BCCHRI
Short Bio:

I work in an area of medicine called developmental pathology, which combines pathology and genetics in the understanding of conditions that affect children. As a Child & Family Research Institute clinical investigator, my research focuses on learning how genetics and epigenetics – chemical modifications to DNA that influence how and when genes are turned on and off – affect human growth and development.

Academic background

  • FCCMG, Cytogenetics. Feb 1989
  • FRCP(C) Anatomical Pathology. 1986
  • MD, University of Calgary, Calgary, Alberta. 1980
  • BA, Concordia College, Moorhead, MN, Biology. 1977

Research Interest

  • Triploidy
  • Fetal growth and development
  • Early pregnancy loss

Summary

Normal fetal growth and development is a complex process with many points at which abnormality may occur. Triploidy and other chromosome abnormalities occur frequently in early pregnancy. Study of triploidy affords insights into the normal processes involved in successful pregnancy and ways in which those processes may be affected by chromosome abnormality. Study of triploid pregnancies yields information on intrauterine growth retardation, imprinting processes in placenta, function of the placenta and its component parts, and reasons for pregnancy losses.

Current Projects

  • To diagnose the underlying defect in miscarriages that have a cytogenetically normal karyotype, and to compare genetic abnormalities in pregnancies conceived naturally with those conceived by IVF.
  • To study X inactivation in early triploid pregnancy losses and to assess correlation of parental origin of triploidy and embryonic/placental phenotype in early pregnancy losses.