I am a Senior Instructor dedicated to undergraduate education, primarily in the Bachelor of Medical Laboratory Science (BMLSc) Program and also in the Medical and Dental Programs. I am also very pleased to be the new Director of the BMLSc Program. This position feels like an extraordinary chance to make a difference and a “good fit”. I have always found teaching to be very rewarding and I am thrilled to have further opportunities to support students, fellow instructors, the program, and our Department.
My academic history: I have a BSc in Biochemistry and a PhD in Experimental Pathology. After several post docs, I became a research associate for the Canadian Blood Services. I enjoyed doing both basic science research (with emphasis on the complement system, RBCs and platelets) and translational work (helping with the early stages of transition to the buffy coat method of preparing blood components). In March 2004, I began wrapping up six years of foundational science research (post PhD) and joined the MD Undergraduate Program (MDUP) as a tenure-track Instructor. I was promoted to Senior Instructor in 2009. I enjoyed 9 years of teaching primarily in the MDUP and look forward to now being dedicated to providing educational leadership and teaching focusing on the BMLSc program.
- A.J. Bradley, B.L. Read, E. Levin, D.V. Devine. Small-molecule complement inhibitors cannot prevent the development of the platelet storage lesion.Transfusion, 2008; 48:706-14.
- A.J. Bradley and M.D. Scott. Immune complex binding by immunocamouflaged [Poly(ethylene glycol) -grafted] Erythrocytes. American Journal of Hematology, 2007; 82:970-975.
- A.J. Bradley and M.D. Scott. Separation and purification of methoxypoly(ethylene glycol) grafted red blood cells via two-phase partitioning. J. Chromatography B, 2004; 163-168.
- M.D. Scott, A.J. Bradley and K.L. Murad. Stealth Erythrocytes: effects of polymer grafting on biophysical, biological, and immunological parameters. Blood Transfusion, 2003; 1:245-266.
- A.J. Bradley, K.L. Murad, K.L.Regan and M.D. Scott. Biophysical consequences
of linker chemistry and polymer size on stealth erythrocytes: Size does matter. Biochim. Biophys. Acta. 2002, 1561:147-158.
- A.J. Bradley, S.T. Test, K.L. Murad, J. Mitsuyoshi and M.D. Scott. Interactions of IgM ABO-antibodies and complement with methoxypoly (ethylene glycol)-modified human erythrocytes. Transfusion, 2001; 41:1225-1233.
- M.D. Scott, A.J. Bradley, and K.L. Murad. Camouflaged blood cells: low technology bioengineering for transfusion medicine? Transfusion Med. Rev., 2000; 14:53-63.
- A.J. Bradley, E. Maurer-Spurej, D.E. Brooks and D.V. Devine. Unusual electrostatic effects on binding of C1q to anionic liposomes: role of anionic phospholipid domains and their line tension. Biochemistry, 1999; 38:8112-8123.
- D.V. Devine, A.J. Bradley, E. Maurer, E. Levin, S. Chahal, K. Serrano and M.I.C. Gyongyossy-Issa. Effects of prestorage leukoreduction on platelet aggregate formation and the activation state of platelets and plasma enzyme systems. Transfusion, 1999; 39:724-734.
- A.J. Bradley, D.E. Brooks, R. Norris-Jones and D.V. Devine. C1q binding to liposomes is surface charge dependent and is inhibited by peptides consisting of residues 14-26 of the human C1qA chain in a sequence independent manner. Biochem. Biophys. Acta, 1999; 1418:19-30.
My current focus is on teaching and learning.
I have foundational science expertise is in the areas of immunology (particularly Complement), biochemistry and hematology. My previous research posed and attempted to answer the following types of questions:
- Does the addition of complement inhibitors to platelet concentrates decrease the platelet storage lesion?
- Does complement play a role in the senescence of RBCs?
- Can adding a polymer coating, specifically using polyethylene glycol (PEG), to RBCs protect mismatched RBCs from complement?
- What are the biophysical consequences of PEGylating RBCs?
- Can PEGylated RBCs still bind immune complexes?
- Can liposome-induced complement activation be inhibited by incorporating PEG onto liposomes?
- What properties determine the complement protein C1q binding to liposomes?
TEACHING & COURSE LEADERSHIP:
My primary commitment is to the Bachelor of Medical Laboratory Science program. As Program Director, I will teach, coordinate and redevelop several courses, striving to use more effective pedagogies. I will contribute to innovative educational practices, support my colleagues and disseminate best practices.
I am a Course Coordinator and teach in the following BMLSC courses: Pathology 300 (Clinical Chemistry section), Pathology 405 (Seminars in Current Topics), Pathology 415 (Immunopathology), and Pathology 408 (Laboratory Administration). I have previously lectured in and been course coordinator for Pathology 402 (Hematopathology).
In the MDUP, I teach first- and second-year medical (and dental) students. I “lecture” and have tutored in the Problem Based Learning (PBL) curriculum; tutored or supervised student projects in the Doctor, Patient and Society course; provided student and faculty support; and, trained new PBL tutors. I am the Week Captain for the 2 Immunology Weeks and the Metabolism Week, in the first-year Principles of Human Biology course. As the Week Captain, I am responsible for all learning activities and assessment for those weeks.
Curriculum development experience includes: incorporating evidence based practice (EBP) into the PBL curriculum, implementing and evaluating the lecture recording pilot (which has, in part, led to a new policy on lecture recording in the MDUP), creating on-line modules for self-study of Immunology, creating a new PBL case, and integrating learning experiences pertaining to immunology and medical microbiology. I have been an active member of three curriculum renewal committees.
I am very honoured to be the recipient of several teaching awards: the 2011 Faculty of Medicine Distinguished Achievement in Education Award, 2010 Department of Pathology Award for Excellence in Education and the 2004-05 Department of Pathology Award for Excellence in Education.
My Teaching Philosophy:
I believe that effective teaching requires a student-centered approach that focuses on opportunities for students to build on their prior knowledge and experiences. A student-centered approach requires appropriate prioritization of the content to ensure that the information is relevant to the students, is at an appropriate level and serves to spark an interest in the topic. Active involvement of students with the material, with the instructor and with each other is crucial. Through discussion and learning activities, students elaborate on what they know and push the boundaries of their knowledge, creating an intrinsic motivation to learn more.
I strive to provide students with an educational experience that is congruent with my beliefs about teaching and learning. To do so, I design (and add-lib) a variety of learning activities that promote student involvement, and I encourage students to take ownership and responsibility for their own learning. Most importantly, I support students as they learn – I cannot do the learning for them (and hence cannot be responsible for their learning), no matter how well-organized and prepared I am as their teacher.